As of November 2025, a new class of AI “reasoning models” has crossed a symbolic line: OpenAI’s GPT‑5 has helped a black hole physicist re-derive hidden symmetries in Kerr spacetime and contributed to fresh results across mathematics, cosmology, and immunology. When an AI can crack a research-level black hole problem that previously demanded months of expert effort, the question is no longer whether AI can do science, but what happens to scientific and corporate R&D when it does.
This article is evergreen content. It explains how emergent reasoning in modern AI models is reshaping discovery, what the GPT‑5 black hole case actually shows, how this fits into the broader “AI for science” movement at OpenAI, DeepMind, and Anthropic, and what it means for your R&D strategy. We’ll finish with a concrete, staged playbook for building an AI-accelerated innovation pipeline.
From text autocompletion to AI co‑scientist
Early large language models (LLMs) like GPT‑3 behaved mostly like supercharged autocompleters: impressive at writing and coding, unreliable at real reasoning. Between 2023 and 2025, three shifts changed that landscape:
- Scaling plus training changes: As documented in multiple 2024–2025 reasoning papers, models tuned for deliberate “thinking” exhibit qualitatively new behaviors: multi-step derivations, case analysis, self-correction loops, and tool use.
- Dedicated reasoning families: OpenAI’s o‑series (o1 in 2024, o3‑pro in June 2025) and GPT‑5’s “thinking” modes, DeepSeek‑R1, and Anthropic’s Claude Opus/Sonnet 4.x families all target long-horizon reasoning rather than just chat.
- Agentic workflows: By 2025, systems like GPT‑5.1 and GPT‑5.1‑Codex‑Max (released November 2025) are routinely orchestrated as agents: reading papers, running code, probing hypotheses, and iterating.
The OpenAI paper Early science acceleration experiments with GPT‑5 (November 20, 2025) crystallizes this shift. It documents, in standardized case studies, how GPT‑5 contributed to ongoing research across mathematics, physics, astronomy, biology, materials science, and high-energy-density physics. Crucially, the authors show not only successes but failure modes, emphasizing that current systems are powerful yet brittle collaborators, not oracles.
What “emergent reasoning” looks like in practice
Recent reasoning research (2024–2025) points to several recurring patterns across frontier models:
- Hierarchy of skills: Abilities like decomposition, induction, and symbolic manipulation appear suddenly when models cross certain scale and training thresholds. Papers on “emergent hierarchical reasoning” and “emergent symbolic mechanisms” show that RL-tuned LLMs can learn internal scratchpad-like structures.
- Stability under scaffolding: Raw model outputs are unreliable. But when wrapped in protocols – e.g., step-by-step prompting, warm-up problems, self-verification, or external tool calls – performance on research-level tasks jumps sharply.
- Domain transfer: A reasoning model primed on one PDE symmetry problem can solve a harder, curved-space analogue; one primed on a convex optimization theorem can propose sharper step-size bounds for a related algorithm.
The GPT‑5 black hole case is a crisp demonstration of all three.
Case study: GPT‑5 and black hole symmetries
The black hole story that triggered this discussion comes from Section I.2 of the GPT‑5 science report: “Discovering new black hole symmetries with GPT‑5 – Alex Lupsasca.” The problem concerns the symmetries of a wave equation on a rotating (Kerr) black hole background – a core object in general relativity tied to tidal response and the now-famous vanishing “Love numbers” of black holes.
The setup:
- Consider the stationary, axisymmetric scalar wave equation on a Kerr background. In suitable coordinates, the PDE has variable coefficients via the Kerr metric’s radial and angular structure.
- Physically, its solutions encode how a black hole responds to static external fields. Mathematically, its symmetries explain rigidity properties like the disappearance of certain tidal deformations.
- In prior human work (Lupsasca 2025), three nontrivial Lie point symmetries forming an SL(2,R) algebra were found using Lie’s algorithm, a technically heavy symbolic computation in curved spacetime.
What GPT‑5 Pro did, as documented in the transcript and paper:
- Cold try fails: Asked directly, “What are the Lie point symmetries of this curved-space PDE?” the model thinks for about 5 minutes and incorrectly reports that there are no nontrivial symmetries.
- Scaffold with a flat-space warm-up: The physicist then gives GPT‑5 a simpler cousin: the axisymmetric Laplace equation in flat space (cylindrical coordinates). This equation has a well-known SL(2,R) conformal symmetry.
- Flat case solved correctly: After ~10 minutes of internal reasoning, GPT‑5 recovers the full set of flat-space generators, including the nontrivial special conformal generator H₋.
- Curved case succeeds: With the same model instance, the physicist re-asks for the symmetries of the Kerr PDE. This time, after ~18 minutes of reasoning, GPT‑5 outputs the correct, fully detailed SL(2,R) generators with the right Kerr-dependent coefficients – matching the human’s earlier result (to which the model had no training-data access).

Why this matters scientifically
Several points make this more than a curious anecdote:
- Nontrivial structure: The final symmetries are too structured to be a lucky guess. They close into the right Lie algebra, depend on the Kerr parameters (M,a) in the correct rational combinations, and reproduce the known flat-space limit.
- Mode of failure and success: The same model that failed cold succeeded after a scaffolded warm-up on a simpler equation sharing the same underlying symmetry. This looks less like database retrieval and more like pattern-activated symbolic reasoning.
- Downstream leverage: Once the symmetry algebra is known, much of the subsequent physics (constraints on tidal response, explanations of vanishing Love numbers) follows with modest work. The AI effectively compressed the hardest conceptual step.
This is the core pattern the GPT‑5 report highlights: when presented as a co‑scientist with well-framed tasks, current models can propose correct structures – from black hole symmetries to integral asymptotics to combinatorial constructions – that meaningfully advance expert research.
AI for science: the new R&D stack
The black hole example doesn’t stand alone. It’s part of a rapidly forming “AI for science” ecosystem across major labs:
- OpenAI: Launched an “AI for Science” initiative in 2025, hired prize-winning black hole physicist Alex Lupsasca, and published the GPT‑5 case-study paper. Models: GPT‑5.1 (general reasoning), GPT‑5.1‑Codex‑Max (November 2025 frontier coding/agent model), and o3‑pro (June 2025 reasoning system card) are positioned as scientific co‑workers for theory, simulation scaffolding, and code-heavy workflows.
- Google DeepMind: AlphaFold 3 (May 2024; code/weights released to academia by November 2024) generalizes protein structure prediction to complexes with DNA, RNA, ligands, and ions and is now coupled to drug discovery pipelines. Follow-on models like AlphaEvolve focus on search over hypothesis spaces with explicit objective functions.
- Anthropic: Claude Sonnet 4 and 4.5 (2025) are tuned for long-running agents, code, and “computer use,” and are used in multi-tool scientific workflows (e.g., literature synthesis + experiment planning + analysis).
- Meta: Llama 4 (April 2025) provides open-weight, multimodal models (Scout, Maverick) that can be customized in-house for domain-specific scientific tasks behind the firewall.
Beyond the model vendors, major trend reports paint a convergent picture:
- The 2025 Stanford AI Index devotes a full chapter to “AI in Science and Medicine,” highlighting that AI-driven methods are now central in structural biology, materials design, and astrophysics.
- The World Economic Forum’s 2024 “Top 10 Emerging Technologies” names “AI for scientific discovery” as #1, explicitly citing its potential to unearth discoveries that would have remained hidden.
- McKinsey (2025) and IQVIA (2025) report 20–30% R&D productivity gains in early adopters through AI augmentation, particularly in documentation, experiment design, and simulation analysis.
| Provider | Flagship 2025 model(s) | Strengths for science/R&D |
|---|---|---|
| OpenAI | GPT‑5.1, GPT‑5.1‑Codex‑Max, o3‑pro | General reasoning, long-context literature synthesis, symbolic math, code generation, agentic workflows |
| Google DeepMind | AlphaFold 3, AlphaEvolve | Biomolecular structure & interaction, objective-driven search in high-dimensional scientific spaces |
| Anthropic | Claude Opus/Sonnet 4.x & 4.5 | Structured analysis, cautious reasoning, complex document synthesis, code-heavy pipelines |
| Meta | Llama 4 Scout/Maverick | Customizable, on-prem/open-weight models for domain-specific scientific tasks and sensitive data |
For corporate R&D leaders, these are not academic curiosities. They signal a shift from “AI as a tool you call” to “AI as a research-grade colleague you manage.”

What changes when AI can solve beyond human experts?
Once you accept that, in certain slices of problem space, AI systems can:
- Suggest correct conjectures and counterexamples
- Complete missing steps in research proofs
- Derive asymptotic expressions and identify symmetry groups
- Design and interpret complex biological or physical experiments
then the structural questions for R&D leaders shift from “Can AI help us?” to “How should we reorganize around AI?” Several implications stand out.
1. The cost of exploration collapses
The classic constraint in both science and corporate innovation is the cost of exploring ideas: each hypothesis, architecture, or design path demands human time. GPT‑5’s case studies show 10×–1000× compressions:
- A convex-optimization theorem whose improved step-size bound might take an expert days to refine is tightened by GPT‑5 in minutes.
- Multi-page immunology experiments on T-cell metabolism are reinterpreted, with mechanistic hypotheses and follow-up experiment trees that would typically take weeks of cross-lab discussion.
- Inertial confinement fusion (ICF) burn-wave modeling that might historically have required a month of postdoc work is prototyped and analyzed in roughly six hours of expert-plus-AI collaboration.
For corporate R&D, this means:
- You can spin up many more “what if we tried X?” branches at negligible marginal cost.
- Frontier models become the first-line filter: we ask AI to propose, rank, and stress-test ideas before committing significant human or compute resources.
2. The value of problem selection rises
When a model can routinely solve the kind of “homework-level” or incremental research questions that still consume a lot of expert time, human comparative advantage shifts to:
- Problem framing: Defining questions that are scientifically or commercially meaningful, not just technically interesting.
- Constraint design: Embedding safety, regulatory, or commercial constraints into what’s worth exploring (e.g., manufacturability, IP landscape, biosecurity guardrails).
- Meta-strategy: Choosing which spaces are high-leverage to explore given company assets, data moats, and risk tolerance.
In this sense, AI for science amplifies – not replaces – humans in the highest-value parts of R&D: deciding where to point the searchlight.
3. Verification and negative space become core skills
Many GPT‑5 case studies stress that while the model can produce correct proofs, derivations, or mechanisms, it also:
- Hallucinates sources or misattributes prior work (e.g., re-deriving Alon’s result on clique-avoiding codes without citation until asked again).
- Overstates the power of standard methods and misses “obvious” blocking counterexamples.
- Optimistically papers over numerical pathologies in simulations unless prodded to fix them.
For R&D organizations, this changes the skill requirements:
- Researchers must be strong enough to audit AI work: to spot when a “beautiful proof” depends on a hidden gap, or when a simulation result is numerical duct tape.
- Teams need explicit verification stages: code review, reproducibility checks, cross-model sanity checks, and alignment with known physical or domain constraints.
4. Talent profiles and training must evolve
The GPT‑5 paper repeatedly highlights a useful mental model: treating the model as a superhumanly broad but occasionally sloppy collaborator, akin to a very fast, somewhat unreliable senior postdoc. That has hiring and upskilling implications:
- Hybrid talent: The most productive scientists and engineers will be those who can both think deeply in their domain and orchestrate AI tools – designing prompts, scaffolds, and verification harnesses.
- Curriculum updates: For PhD training and internal corporate academies, skills like “LLM-augmented literature search,” “AI-assisted proof engineering,” and “agent-based experiment planning” should become standard.
Designing an AI-augmented innovation pipeline
Translating this paradigm shift into a concrete R&D strategy means embedding AI for science across the entire pipeline, not just at the “assistant” edge. Below is a staged blueprint you can adapt.
Stage 1: Foundation – models, data, and governance
- Choose your model mix (closed + open)
For deep reasoning, you’ll likely combine:- A frontier closed model (e.g., GPT‑5.1/o3‑pro, Claude Sonnet 4.x) via API for hardest reasoning and multi-tool agents.
- An open-weight stack (e.g., Llama 4 or Llama 3.x variants) fine-tuned on your domain data and deployable on-prem for IP- and privacy-sensitive workloads.
- Set up data access and toolchains
Integrate:- Internal literature, lab notebooks, ELNs, simulation outputs, and design repositories into searchable knowledge graphs or vector stores.
- Domain tools (e.g., COMSOL, Ansys, Gaussian, custom physics solvers, cheminformatics platforms) with programmatic interfaces AI agents can call.
- Establish AI governance for R&D
Define:- Which models can touch which data; where open vs closed models are allowed.
- Review requirements for AI-generated hypotheses, code, or analyses before they inform go/no-go decisions.
Stage 2: AI for exploration – idea generation and triage
- AI-augmented landscape scans
Use long-context reasoning models (GPT‑5.1/Claude) to:- Synthesize recent literature and patents into opportunity maps.
- Identify gaps, convergent trends, and contradictory findings.
- Hypothesis factories
Implement repeatable workflows where AI:- Generates N alternative hypotheses or design concepts for a targeted problem.
- Ranks them by plausibility, novelty, and tractability, citing supporting or conflicting evidence.
- Early risk and feasibility assessment
Ask models to:- Flag regulatory, safety, or manufacturability red flags.
- Estimate data and compute requirements and suggest minimal viable experiments.
Stage 3: AI for design – experiments, simulations, and architectures
- AI-designed experiment trees
Following patterns from GPT‑5’s immunology and CAR‑T case studies:- Have AI propose tiered experiment sets: mechanism-disambiguating “decision tree” experiments, controls, and follow-ons.
- Include predicted outcomes and how each outcome updates the model of the system.
- Simulation scaffolding and reduced models
Use models akin to what GPT‑5 did for ICF:- Ask for reduced-physics models capturing essential dynamics (e.g., burn-wave propagation, diffusion-reaction fronts, stress fields) as PDEs or ODEs.
- Generate prototype code (Python/Julia/C++) and simple parameter sweeps to map regimes before committing to heavy 3D runs.
- Architecture and design search
In domains like materials, devices, or algorithms:- Use agentic models (GPT‑5.1‑Codex‑Max, Llama 4-based agents) to explore design spaces: e.g., multi-layer stack designs, control strategies, or learning architectures.
- Pair them with objective evaluators (simulators, fast surrogates, empirical scoring functions).

Stage 4: AI for analysis – interpretation, verification, and synthesis
- Automated analysis drafts
Feed experimental or simulation outputs (figures, logs, metrics) into AI systems to:- Produce first-pass interpretations, trend descriptions, and anomaly detection.
- Propose mechanistic explanations and alternative fits.
- Cross-checking and replication
Use:- Multiple models (OpenAI vs Claude vs Llama 4) to independently analyze the same data.
- Automated symbolic/numeric verifiers (e.g., computer algebra systems, formal proof assistants where practical) for critical derivations and algorithms.
- Living knowledge bases
Continuously distill verified insights into internal wikis and knowledge graphs that AI agents can query, ensuring that future reasoning is grounded in what your organization has already validated.
Stage 5: Organizational integration and measurement
- Define AI contribution metrics
Track:- Fraction of projects where AI materially contributed to hypotheses, designs, or analyses (self-reported + retrospective review).
- Cycle time from idea to validated experiment or prototype, pre- vs post‑AI integration.
- Hit rate: proportion of AI-suggested paths that led to promising leads vs dead ends.
- Align incentives
Reward:- Researchers who share effective AI workflows, prompts, and verification harnesses.
- Teams that demonstrate faster, more rigorous innovation with AI, not just more AI usage.
- Continuously update model and tool choices
Given the pace of releases – GPT‑4.1 (April 2025), GPT‑5.1 (November 2025), Llama 4 (April 2025), Claude 4.x/4.5 (2025) – treat your AI stack as a rolling program, with quarterly assessments of capability, cost, and alignment with your R&D roadmap.
How to prepare now
The GPT‑5 black hole example is a leading indicator, not an anomaly. Across fields, we now have documented instances of AI:
- Deriving new mathematical results and tightening existing theorems.
- Finding non-obvious mechanisms in biological data and suggesting experiments that replicate in the lab.
- Designing and analyzing reduced-physics models to explore complex physical regimes.
- Solving open combinatorial problems and refuting naive algorithms with subtle counterexamples.
For scientific and corporate R&D leaders, three practical next steps follow:
- Run focused pilots: Choose 2–3 representative projects (theoretical, simulation-heavy, experimental). Embed a frontier reasoning model as a co‑investigator and measure time-to-insight adjustments.
- Build an internal “AI for science” guild: A small cross-functional group (domain scientists, ML engineers, tooling specialists) tasked with codifying best practices, prompts, and guardrails.
- Invest in verification culture: Make it explicit that AI is expected to propose bold ideas and that rigorous human and tool-based checking is non-negotiable.
As emergent reasoning models continue to improve and specialized systems like AlphaFold 3 spread, the competitive frontier in R&D will increasingly be set not by who “has AI” but by who can architect their innovation pipelines around AI co‑scientists. The organizations that adapt their strategy, workflows, and talent to this new reality will be the ones that turn AI’s raw reasoning power into durable scientific and commercial advantage.